Drug interactions
Doxycycline + Infigratinib
Severity: Minor
Doxycycline and Infigratinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib is a CYP3A4 substrate, but doxycycline is not a clinically important CYP3A4 inhibitor. A meaningful increase in infigratinib exposure is unlikely.
What this interaction means in plain words
Doxycycline and Infigratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition, not established for doxycycline.
What to do
No dose adjustment is routinely needed; monitor for hyperphosphatemia and ocular toxicity as part of normal infigratinib care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Infigratinib?
MediHelp rates the interaction as minor. Doxycycline and Infigratinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Infigratinib is a CYP3A4 substrate, but doxycycline is not a clinically important CYP3A4 inhibitor. A meaningful increase in infigratinib exposure is unlikely.
How serious is the interaction between Doxycycline and Infigratinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed; monitor for hyperphosphatemia and ocular toxicity as part of normal infigratinib care.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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