Drug interactions
Doxycycline + Methotrexate
Severity: Moderate
Doxycycline and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetracyclines have been reported to increase methotrexate levels and toxicity in some cases, although data are limited. The effect may be more important at high methotrexate doses or with renal impairment.
What this interaction means in plain words
Doxycycline and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Methotrexate belongs to Oncology.
Why it happens
Possible reduced renal clearance of methotrexate; the mechanism is not firmly established.
What to do
Monitor blood counts and renal function when combining, particularly with higher methotrexate doses. Reduce methotrexate dose if signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Methotrexate?
MediHelp rates the interaction as moderate. Doxycycline and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetracyclines have been reported to increase methotrexate levels and toxicity in some cases, although data are limited. The effect may be more important at high methotrexate doses or with renal impairment.
How serious is the interaction between Doxycycline and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function when combining, particularly with higher methotrexate doses. Reduce methotrexate dose if signs of toxicity appear.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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