Drug interactions
Doxycycline + Mipomersen
Severity: Moderate
Doxycycline and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen is associated with hepatotoxicity, including raised transaminases and hepatic fat accumulation. Doxycycline can uncommonly cause liver enzyme elevations, so combined use may make liver injury harder to detect or attribute and could add to hepatic stress.
What this interaction means in plain words
Doxycycline and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential through pharmacodynamic overlap; no pharmacokinetic interaction is established.
What to do
Check ALT, AST and bilirubin before and during combined therapy, in line with mipomersen monitoring requirements. Stop the offending drug if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Mipomersen?
MediHelp rates the interaction as moderate. Doxycycline and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen is associated with hepatotoxicity, including raised transaminases and hepatic fat accumulation. Doxycycline can uncommonly cause liver enzyme elevations, so combined use may make liver injury harder to detect or attribute and could add to hepatic stress.
How serious is the interaction between Doxycycline and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ALT, AST and bilirubin before and during combined therapy, in line with mipomersen monitoring requirements. Stop the offending drug if transaminases rise significantly.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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