Drug interactions
Doxycycline + Selumetinib
Severity: Minor
Doxycycline and Selumetinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selumetinib is metabolized primarily by CYP3A4, so inhibitors can increase exposure and toxicity. Doxycycline is not an established CYP3A4 inhibitor, so the effect is likely minimal.
What this interaction means in plain words
Doxycycline and Selumetinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Selumetinib belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 inhibition by doxycycline.
What to do
No dose adjustment; monitor for gastrointestinal, skin and ocular adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Selumetinib
Frequently asked questions
Can I take Doxycycline with Selumetinib?
MediHelp rates the interaction as minor. Doxycycline and Selumetinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selumetinib is metabolized primarily by CYP3A4, so inhibitors can increase exposure and toxicity. Doxycycline is not an established CYP3A4 inhibitor, so the effect is likely minimal.
How serious is the interaction between Doxycycline and Selumetinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment; monitor for gastrointestinal, skin and ocular adverse effects as usual.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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