Drug interactions
Doxycycline + Sufentanil sl
Severity: Minor
Doxycycline and Sufentanil sl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is metabolized by CYP3A4, and strong inhibitors can raise levels and cause dangerous respiratory depression. Doxycycline is not a recognized CYP3A4 inhibitor, so a meaningful interaction is unlikely.
What this interaction means in plain words
Doxycycline and Sufentanil sl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical CYP3A4 inhibition by doxycycline that is not supported by clinical data.
What to do
No adjustment is needed. Continue standard monitoring for sedation and respiratory depression with sufentanil.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Sufentanil sl?
MediHelp rates the interaction as minor. Doxycycline and Sufentanil sl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sufentanil is metabolized by CYP3A4, and strong inhibitors can raise levels and cause dangerous respiratory depression. Doxycycline is not a recognized CYP3A4 inhibitor, so a meaningful interaction is unlikely.
How serious is the interaction between Doxycycline and Sufentanil sl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Continue standard monitoring for sedation and respiratory depression with sufentanil.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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