Drug interactions
Doxycycline + Temocillin
Severity: Moderate
Doxycycline and Temocillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines may blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. This has been shown mainly in vitro and in some older clinical observations in serious infections such as meningitis. The clinical significance is uncertain for most infections.
What this interaction means in plain words
Doxycycline and Temocillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: protein synthesis inhibition reduces bacterial growth, limiting the bactericidal action of cell-wall active beta-lactams.
What to do
Avoid combining in severe infections where bactericidal activity is essential, such as meningitis or endocarditis. Otherwise combine only if there is a clear indication for both agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Temocillin?
MediHelp rates the interaction as moderate. Doxycycline and Temocillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the killing activity of beta-lactams, which depend on actively dividing bacteria. This has been shown mainly in vitro and in some older clinical observations in serious infections such as meningitis. The clinical significance is uncertain for most infections.
How serious is the interaction between Doxycycline and Temocillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining in severe infections where bactericidal activity is essential, such as meningitis or endocarditis. Otherwise combine only if there is a clear indication for both agents.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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