Drug interactions
Doxycycline + Tofacitinib
Severity: Minor
Doxycycline and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxycycline is not a clinically meaningful CYP3A4 inhibitor, and no important effect on tofacitinib exposure is expected.
What this interaction means in plain words
Doxycycline and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Tofacitinib belongs to Musculoskeletal.
Why it happens
No established pharmacokinetic mechanism.
What to do
No adjustment needed; routine monitoring for infection applies.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Tofacitinib?
MediHelp rates the interaction as minor. Doxycycline and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Doxycycline is not a clinically meaningful CYP3A4 inhibitor, and no important effect on tofacitinib exposure is expected.
How serious is the interaction between Doxycycline and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment needed; routine monitoring for infection applies.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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