Drug interactions
Doxylamine + Imipramine
Severity: Moderate
Doxylamine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine with anticholinergic effects that add to those of imipramine. The combination can cause excessive drowsiness, confusion, dry mouth, urinary retention and impaired psychomotor performance.
What this interaction means in plain words
Doxylamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and antimuscarinic effects.
What to do
Avoid regular use of doxylamine as a hypnotic in patients taking imipramine, especially older adults. Monitor for sedation and anticholinergic symptoms if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Doxylamine and Imipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Imipramine?
MediHelp rates the interaction as moderate. Doxylamine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine with anticholinergic effects that add to those of imipramine. The combination can cause excessive drowsiness, confusion, dry mouth, urinary retention and impaired psychomotor performance.
How serious is the interaction between Doxylamine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use of doxylamine as a hypnotic in patients taking imipramine, especially older adults. Monitor for sedation and anticholinergic symptoms if used.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
