Drug interactions
Doxylamine + Lorazepam
Severity: Moderate
Doxylamine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a sedating antihistamine that adds to the sedative effect of lorazepam. This increases daytime drowsiness, impaired coordination and fall risk.
What this interaction means in plain words
Doxylamine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and central H1 receptor blockade.
What to do
Avoid combining the two as sleep aids and use the lowest effective doses. Counsel against driving and alcohol, and be especially cautious in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Lorazepam?
MediHelp rates the interaction as moderate. Doxylamine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a sedating antihistamine that adds to the sedative effect of lorazepam. This increases daytime drowsiness, impaired coordination and fall risk.
How serious is the interaction between Doxylamine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two as sleep aids and use the lowest effective doses. Counsel against driving and alcohol, and be especially cautious in older adults.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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