Drug interactions
Doxylamine + Oxazepam
Severity: Moderate
Doxylamine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine, and with oxazepam it can cause marked drowsiness and next-day impairment of alertness and driving.
What this interaction means in plain words
Doxylamine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxylamine belongs to Respiratory; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from central H1 antagonism and benzodiazepine GABA-A potentiation.
What to do
Avoid combining the two as sleep aids and counsel against driving and alcohol. Monitor older patients for confusion and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Doxylamine
Frequently asked questions
Can I take Doxylamine with Oxazepam?
MediHelp rates the interaction as moderate. Doxylamine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine, and with oxazepam it can cause marked drowsiness and next-day impairment of alertness and driving.
How serious is the interaction between Doxylamine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two as sleep aids and counsel against driving and alcohol. Monitor older patients for confusion and falls.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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