Drug interactions
Droperidol + Fluticasone-vilanterol
Severity: Major
Droperidol and Fluticasone-vilanterol: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol carries a boxed warning for QT prolongation and torsade de pointes. Vilanterol may add to arrhythmic risk through beta-agonist effects on heart rate and potassium.
What this interaction means in plain words
Droperidol and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation with beta2-agonist-induced hypokalemia and tachycardia.
What to do
Obtain an ECG before droperidol and monitor during and after administration. Correct electrolytes and consider an alternative antiemetic in high-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Droperidol with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Droperidol and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol carries a boxed warning for QT prolongation and torsade de pointes. Vilanterol may add to arrhythmic risk through beta-agonist effects on heart rate and potassium.
How serious is the interaction between Droperidol and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before droperidol and monitor during and after administration. Correct electrolytes and consider an alternative antiemetic in high-risk patients.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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