Drug interactions
Droperidol + Hydroxyzine
Severity: Contraindicated
Droperidol and Hydroxyzine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and hydroxyzine adds to this effect. Together they may substantially raise the risk of life-threatening arrhythmia.
What this interaction means in plain words
Droperidol and Hydroxyzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive QTc prolongation through blockade of cardiac potassium channels.
What to do
Do not combine; use a non-QT-prolonging alternative for nausea or sedation. If droperidol has been given, avoid hydroxyzine and monitor ECG.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Droperidol and Hydroxyzine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydroxyzine
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
- Amisulpride + Hydroxyzine Major
Frequently asked questions
Can I take Droperidol with Hydroxyzine?
MediHelp rates the interaction as contraindicated. Droperidol and Hydroxyzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Droperidol carries a boxed warning for QT prolongation and torsades de pointes, and hydroxyzine adds to this effect. Together they may substantially raise the risk of life-threatening arrhythmia.
How serious is the interaction between Droperidol and Hydroxyzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging alternative for nausea or sedation. If droperidol has been given, avoid hydroxyzine and monitor ECG.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Hydroxyzine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
