Drug interactions
Hydroxyzine + Vandetanib
Severity: Contraindicated
Hydroxyzine and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death, and hydroxyzine adds further QT risk. Co-use with other QT-prolonging drugs should be avoided.
What this interaction means in plain words
Hydroxyzine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxyzine belongs to Respiratory; Vandetanib belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Do not combine; use a non-QT-prolonging alternative to hydroxyzine. Vandetanib patients need ECG and electrolyte monitoring regardless.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
- Amisulpride + Hydroxyzine Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxyzine with Vandetanib?
MediHelp rates the interaction as contraindicated. Hydroxyzine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib has a boxed warning for QT prolongation, torsades de pointes and sudden death, and hydroxyzine adds further QT risk. Co-use with other QT-prolonging drugs should be avoided.
How serious is the interaction between Hydroxyzine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use a non-QT-prolonging alternative to hydroxyzine. Vandetanib patients need ECG and electrolyte monitoring regardless.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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