Drug interactions
Droperidol + Metaxalone
Severity: Moderate
Droperidol and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating antipsychotic and antiemetic, and it adds to the CNS depressant effect of metaxalone. Droperidol also prolongs the QT interval, which is a separate safety concern in treated patients.
What this interaction means in plain words
Droperidol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine antagonism with antihistaminic effects plus the sedating action of metaxalone.
What to do
Monitor sedation level and reduce the dose of either agent if oversedation occurs. Obtain an ECG and correct electrolytes per droperidol labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Frequently asked questions
Can I take Droperidol with Metaxalone?
MediHelp rates the interaction as moderate. Droperidol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is a sedating antipsychotic and antiemetic, and it adds to the CNS depressant effect of metaxalone. Droperidol also prolongs the QT interval, which is a separate safety concern in treated patients.
How serious is the interaction between Droperidol and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and reduce the dose of either agent if oversedation occurs. Obtain an ECG and correct electrolytes per droperidol labeling.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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