Drug interactions
Droperidol + Oxymorphone
Severity: Major
Droperidol and Oxymorphone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating neuroleptic and may add to oxymorphone's CNS and respiratory depression and hypotension. Droperidol also carries a QT prolongation risk of its own.
What this interaction means in plain words
Droperidol and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression and hypotension from dopamine antagonism and alpha-blockade combined with opioid agonism.
What to do
Use reduced doses and monitor respiration, blood pressure and ECG as appropriate. Ensure equipment and staff are available to manage respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Droperidol with Oxymorphone?
MediHelp rates the interaction as major. Droperidol and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Droperidol is a sedating neuroleptic and may add to oxymorphone's CNS and respiratory depression and hypotension. Droperidol also carries a QT prolongation risk of its own.
How serious is the interaction between Droperidol and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced doses and monitor respiration, blood pressure and ECG as appropriate. Ensure equipment and staff are available to manage respiratory depression.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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