Drug interactions
Droperidol + Ziprasidone
Severity: Contraindicated
Droperidol and Ziprasidone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol carries a boxed warning for QT prolongation and torsades de pointes. Combining it with ziprasidone increases the likelihood of dangerous ventricular arrhythmias.
What this interaction means in plain words
Droperidol and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive hERG potassium channel blockade leading to additive QT prolongation.
What to do
Avoid concurrent use and choose a non-QT-prolonging antiemetic or sedative. If droperidol has been given, delay ziprasidone until the drug has cleared and the ECG is acceptable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Droperidol with Ziprasidone?
MediHelp rates the interaction as contraindicated. Droperidol and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Droperidol carries a boxed warning for QT prolongation and torsades de pointes. Combining it with ziprasidone increases the likelihood of dangerous ventricular arrhythmias.
How serious is the interaction between Droperidol and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a non-QT-prolonging antiemetic or sedative. If droperidol has been given, delay ziprasidone until the drug has cleared and the ECG is acceptable.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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