Drug interactions
Drospirenone + Epoprostenol
Severity: Minor
Drospirenone and Epoprostenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol is a potent vasodilator that lowers blood pressure. Drospirenone has mild antimineralocorticoid effects and a small blood pressure lowering tendency. Any additive hypotensive effect is expected to be small.
What this interaction means in plain words
Drospirenone and Epoprostenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Epoprostenol belongs to Genitourinary.
Why it happens
Additive vasodilatory and hypotensive pharmacodynamic effects, predicted rather than demonstrated.
What to do
No dose change is needed; monitor blood pressure as part of routine epoprostenol therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Epoprostenol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Drospirenone
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Drospirenone with Epoprostenol?
MediHelp rates the interaction as minor. Drospirenone and Epoprostenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epoprostenol is a potent vasodilator that lowers blood pressure. Drospirenone has mild antimineralocorticoid effects and a small blood pressure lowering tendency. Any additive hypotensive effect is expected to be small.
How serious is the interaction between Drospirenone and Epoprostenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure as part of routine epoprostenol therapy.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
