Drug interactions
Drospirenone + Flurbiprofen
Severity: Moderate
Drospirenone and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs reduce renal potassium excretion. The combination may cause hyperkalemia, mainly in patients with renal impairment or other potassium-raising drugs, though routine short-term use in healthy women is rarely problematic.
What this interaction means in plain words
Drospirenone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Aldosterone antagonism by drospirenone plus NSAID-induced suppression of renin-aldosterone and reduced renal function additively increase potassium.
What to do
In the first cycle of use with long-term NSAIDs, check serum potassium, especially with renal impairment or other potassium-raising drugs. Avoid the combination in significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Flurbiprofen?
MediHelp rates the interaction as moderate. Drospirenone and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs reduce renal potassium excretion. The combination may cause hyperkalemia, mainly in patients with renal impairment or other potassium-raising drugs, though routine short-term use in healthy women is rarely problematic.
How serious is the interaction between Drospirenone and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In the first cycle of use with long-term NSAIDs, check serum potassium, especially with renal impairment or other potassium-raising drugs. Avoid the combination in significant renal impairment.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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