Drug interactions
Drospirenone + Fluticasone-salmeterol
Severity: Minor
Drospirenone and Fluticasone-salmeterol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, while salmeterol tends to lower it. The effects oppose each other, so the net change is generally small and unpredictable.
What this interaction means in plain words
Drospirenone and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Opposing potassium effects: beta2-agonist cellular uptake versus aldosterone antagonism by drospirenone.
What to do
No routine action is needed; check potassium if the patient has renal impairment or takes other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Fluticasone-salmeterol?
MediHelp rates the interaction as minor. Drospirenone and Fluticasone-salmeterol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise potassium, while salmeterol tends to lower it. The effects oppose each other, so the net change is generally small and unpredictable.
How serious is the interaction between Drospirenone and Fluticasone-salmeterol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check potassium if the patient has renal impairment or takes other potassium-raising drugs.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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