Drug interactions
Drospirenone + Glipizide-metformin
Severity: Minor
Drospirenone and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone-containing contraceptives can slightly impair glucose tolerance, possibly blunting antidiabetic effect. Drospirenone also has potassium-sparing activity, which is relevant in renal impairment.
What this interaction means in plain words
Drospirenone and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Glipizide-metformin belongs to Endocrine.
Why it happens
Hormonal effects on insulin sensitivity oppose antidiabetic action.
What to do
Monitor glucose after starting or stopping the contraceptive and adjust antidiabetic doses if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Glipizide-metformin?
MediHelp rates the interaction as minor. Drospirenone and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone-containing contraceptives can slightly impair glucose tolerance, possibly blunting antidiabetic effect. Drospirenone also has potassium-sparing activity, which is relevant in renal impairment.
How serious is the interaction between Drospirenone and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose after starting or stopping the contraceptive and adjust antidiabetic doses if needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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