Drug interactions
Drospirenone + Hydrochlorothiazide-telmisartan
Severity: Moderate
Drospirenone and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and telmisartan reduces aldosterone effect, both of which promote potassium retention. Hydrochlorothiazide partly offsets this by increasing potassium loss, so the net effect varies, but hyperkalemia can still occur, especially with renal impairment.
What this interaction means in plain words
Drospirenone and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Additive potassium-retaining effects from angiotensin receptor blockade and drospirenone's antialdosterone activity, partly opposed by thiazide kaliuresis.
What to do
Check serum potassium and renal function during the first cycle of treatment and periodically afterward. Avoid the combination in patients with renal impairment or other risk factors for hyperkalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Drospirenone and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and telmisartan reduces aldosterone effect, both of which promote potassium retention. Hydrochlorothiazide partly offsets this by increasing potassium loss, so the net effect varies, but hyperkalemia can still occur, especially with renal impairment.
How serious is the interaction between Drospirenone and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function during the first cycle of treatment and periodically afterward. Avoid the combination in patients with renal impairment or other risk factors for hyperkalemia.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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