Drug interactions
Drospirenone + Hydrochlorothiazide-valsartan
Severity: Moderate
Drospirenone and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and retains potassium, which adds to the effect of valsartan. Hydrochlorothiazide partly counters this, but hyperkalemia remains possible, especially with renal impairment.
What this interaction means in plain words
Drospirenone and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive potassium retention from angiotensin receptor blockade and the antimineralocorticoid action of drospirenone, partly offset by thiazide potassium loss.
What to do
Measure serum potassium during the first cycle of treatment and periodically thereafter. Consider a different contraceptive in patients with renal impairment or a high baseline potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Drospirenone and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and retains potassium, which adds to the effect of valsartan. Hydrochlorothiazide partly counters this, but hyperkalemia remains possible, especially with renal impairment.
How serious is the interaction between Drospirenone and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first cycle of treatment and periodically thereafter. Consider a different contraceptive in patients with renal impairment or a high baseline potassium.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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