Drug interactions
Drospirenone + Ibuprofen
Severity: Moderate
Drospirenone and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and NSAIDs can also promote potassium retention. In most healthy women the effect is small, but risk rises with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Ibuprofen belongs to Musculoskeletal.
Why it happens
Additive potassium retention from drospirenone aldosterone antagonism and NSAID suppression of renin-aldosterone axis and renal perfusion.
What to do
Check serum potassium in the first cycle in patients on long-term NSAIDs, especially with renal impairment or other potassium-raising drugs. Occasional ibuprofen use generally needs no extra measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Ibuprofen?
MediHelp rates the interaction as moderate. Drospirenone and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium, and NSAIDs can also promote potassium retention. In most healthy women the effect is small, but risk rises with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle in patients on long-term NSAIDs, especially with renal impairment or other potassium-raising drugs. Occasional ibuprofen use generally needs no extra measures.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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