Drug interactions
Drospirenone + Insulin degludec-liraglutide
Severity: Minor
Drospirenone and Insulin degludec-liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone-containing contraceptives may slightly impair glucose tolerance, which could modestly reduce the effect of insulin degludec-liraglutide. Drospirenone also has potassium-sparing properties, but this is not meaningfully relevant to this pairing.
What this interaction means in plain words
Drospirenone and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Hormonal contraceptives may modestly reduce insulin sensitivity, opposing antidiabetic drugs.
What to do
Monitor blood glucose when the contraceptive is started or stopped, and adjust antidiabetic doses only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Insulin degludec-liraglutide?
MediHelp rates the interaction as minor. Drospirenone and Insulin degludec-liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone-containing contraceptives may slightly impair glucose tolerance, which could modestly reduce the effect of insulin degludec-liraglutide. Drospirenone also has potassium-sparing properties, but this is not meaningfully relevant to this pairing.
How serious is the interaction between Drospirenone and Insulin degludec-liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when the contraceptive is started or stopped, and adjust antidiabetic doses only if control changes.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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