Drug interactions
Drospirenone + Lisinopril
Severity: Moderate
Drospirenone and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Combined with an ACE inhibitor, hyperkalemia may occur, particularly with renal impairment.
What this interaction means in plain words
Drospirenone and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Lisinopril belongs to Cardiovascular.
Why it happens
Drospirenone blocks the mineralocorticoid receptor while ACE inhibition reduces aldosterone, giving additive potassium retention.
What to do
Check serum potassium during the first cycle of combined use. Consider a different contraceptive in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Lisinopril?
MediHelp rates the interaction as moderate. Drospirenone and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Combined with an ACE inhibitor, hyperkalemia may occur, particularly with renal impairment.
How serious is the interaction between Drospirenone and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use. Consider a different contraceptive in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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