Drug interactions
Drospirenone + Mavacamten
Severity: Major
Drospirenone and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten may reduce drospirenone exposure, raising the risk of contraceptive failure and breakthrough bleeding. Pregnancy prevention is important during mavacamten therapy.
What this interaction means in plain words
Drospirenone and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Drospirenone belongs to Endocrine; Mavacamten belongs to Cardiovascular.
Why it happens
Mavacamten induces CYP3A4, increasing drospirenone metabolism.
What to do
Use a method unaffected by enzyme induction, such as an IUD, or add barrier contraception during treatment and for several months after the last dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Drospirenone
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Drospirenone with Mavacamten?
MediHelp rates the interaction as major. Drospirenone and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten may reduce drospirenone exposure, raising the risk of contraceptive failure and breakthrough bleeding. Pregnancy prevention is important during mavacamten therapy.
How serious is the interaction between Drospirenone and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a method unaffected by enzyme induction, such as an IUD, or add barrier contraception during treatment and for several months after the last dose.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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