Drug interactions
Drospirenone + Meclofenamic acid
Severity: Moderate
Drospirenone and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs reduce renal prostaglandin-mediated potassium excretion and renin release. Combined use may cause hyperkalemia, particularly in patients with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive hyperkalemic effect: aldosterone antagonism by drospirenone plus NSAID-induced suppression of renin and aldosterone.
What to do
Check serum potassium in the first cycle of concurrent long-term NSAID use and periodically afterward. Avoid in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Meclofenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Meclofenamic acid?
MediHelp rates the interaction as moderate. Drospirenone and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs reduce renal prostaglandin-mediated potassium excretion and renin release. Combined use may cause hyperkalemia, particularly in patients with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first cycle of concurrent long-term NSAID use and periodically afterward. Avoid in patients with renal impairment.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
