Drug interactions
Drospirenone + Meloxicam
Severity: Moderate
Drospirenone and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs can add to this effect. Risk is mainly relevant in patients with renal impairment or those taking other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Meloxicam belongs to Musculoskeletal.
Why it happens
Drospirenone antagonizes aldosterone while NSAIDs suppress renin-aldosterone and reduce renal potassium excretion.
What to do
In patients with renal impairment or on other potassium-raising drugs, check serum potassium during the first cycle. Otherwise no routine action is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Meloxicam?
MediHelp rates the interaction as moderate. Drospirenone and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs can add to this effect. Risk is mainly relevant in patients with renal impairment or those taking other potassium-raising drugs.
How serious is the interaction between Drospirenone and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients with renal impairment or on other potassium-raising drugs, check serum potassium during the first cycle. Otherwise no routine action is needed.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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