Drug interactions
Drospirenone + Moexipril
Severity: Moderate
Drospirenone and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Together with an ACE inhibitor, the risk of hyperkalemia increases, particularly with renal impairment.
What this interaction means in plain words
Drospirenone and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
Additive potassium retention: aldosterone antagonism by drospirenone and reduced aldosterone production through ACE inhibition.
What to do
Check serum potassium during the first cycle of combined use. Avoid in patients with renal impairment or other hyperkalemia risks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Moexipril?
MediHelp rates the interaction as moderate. Drospirenone and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Together with an ACE inhibitor, the risk of hyperkalemia increases, particularly with renal impairment.
How serious is the interaction between Drospirenone and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use. Avoid in patients with renal impairment or other hyperkalemia risks.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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