Drug interactions
Drospirenone + Naproxen
Severity: Moderate
Drospirenone and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs add to this risk. Hyperkalemia is mostly relevant in patients with renal impairment or on other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Additive potassium retention from drospirenone's antimineralocorticoid effect and NSAID-induced suppression of renin and aldosterone.
What to do
In high-risk patients, check serum potassium during the first cycle of concurrent use. Occasional NSAID use in healthy women rarely needs action.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Naproxen?
MediHelp rates the interaction as moderate. Drospirenone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise potassium, and NSAIDs add to this risk. Hyperkalemia is mostly relevant in patients with renal impairment or on other potassium-raising drugs.
How serious is the interaction between Drospirenone and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In high-risk patients, check serum potassium during the first cycle of concurrent use. Occasional NSAID use in healthy women rarely needs action.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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