Drug interactions
Drospirenone + Propranolol
Severity: Minor
Drospirenone and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and nonselective beta-blockers may also modestly impair cellular potassium uptake. Together they may contribute to hyperkalemia, mainly in patients with renal impairment or other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Propranolol belongs to Cardiovascular.
Why it happens
Drospirenone's antialdosterone effect reduces potassium excretion, while beta-blockade reduces beta-2 mediated cellular potassium uptake.
What to do
Check serum potassium in the first treatment cycle in patients with renal impairment or other potassium-raising drugs. Avoid the combination where hyperkalemia risk is high.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Propranolol?
MediHelp rates the interaction as minor. Drospirenone and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and nonselective beta-blockers may also modestly impair cellular potassium uptake. Together they may contribute to hyperkalemia, mainly in patients with renal impairment or other potassium-raising drugs.
How serious is the interaction between Drospirenone and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in the first treatment cycle in patients with renal impairment or other potassium-raising drugs. Avoid the combination where hyperkalemia risk is high.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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