Drug interactions
Drospirenone + Ramipril
Severity: Moderate
Drospirenone and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is a progestin with antimineralocorticoid activity that can raise serum potassium. Together with ramipril, which also reduces aldosterone-mediated potassium excretion, the risk of hyperkalemia is increased.
What this interaction means in plain words
Drospirenone and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Ramipril belongs to Cardiovascular.
Why it happens
Additive potassium retention through ACE inhibition and aldosterone antagonism by drospirenone.
What to do
Measure serum potassium during the first cycle of combined use and periodically thereafter, especially in patients with renal impairment; consider a different contraceptive if hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Ramipril?
MediHelp rates the interaction as moderate. Drospirenone and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone is a progestin with antimineralocorticoid activity that can raise serum potassium. Together with ramipril, which also reduces aldosterone-mediated potassium excretion, the risk of hyperkalemia is increased.
How serious is the interaction between Drospirenone and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum potassium during the first cycle of combined use and periodically thereafter, especially in patients with renal impairment; consider a different contraceptive if hyperkalemia develops.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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