Drug interactions
Drospirenone + Sacubitril-valsartan
Severity: Moderate
Drospirenone and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can increase potassium. With an angiotensin receptor blocker, hyperkalemia risk rises, particularly in renal impairment.
What this interaction means in plain words
Drospirenone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Additive reduction in aldosterone-mediated potassium excretion from drospirenone and valsartan.
What to do
Check serum potassium during the first cycle of combined use and periodically after. Consider a contraceptive without antimineralocorticoid activity in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Drospirenone and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can increase potassium. With an angiotensin receptor blocker, hyperkalemia risk rises, particularly in renal impairment.
How serious is the interaction between Drospirenone and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of combined use and periodically after. Consider a contraceptive without antimineralocorticoid activity in high-risk patients.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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