Drug interactions
Drospirenone + Somapacitan
Severity: Minor
Drospirenone and Somapacitan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, which can blunt the response to growth hormone analogs. This applies to estrogen-containing products, and drospirenone alone is not expected to share this effect.
What this interaction means in plain words
Drospirenone and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Estrogen component, not drospirenone itself, attenuates hepatic IGF-1 response to growth hormone.
What to do
If drospirenone is given with oral estrogen, monitor IGF-1 and adjust somapacitan dose accordingly; progestin-only use needs no change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Drospirenone
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Drospirenone with Somapacitan?
MediHelp rates the interaction as minor. Drospirenone and Somapacitan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral estrogens reduce hepatic IGF-1 production in response to growth hormone, which can blunt the response to growth hormone analogs. This applies to estrogen-containing products, and drospirenone alone is not expected to share this effect.
How serious is the interaction between Drospirenone and Somapacitan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If drospirenone is given with oral estrogen, monitor IGF-1 and adjust somapacitan dose accordingly; progestin-only use needs no change.
What other medicines interact with Drospirenone?
MediHelp also lists interactions of Drospirenone with, for example, Belzutifan, Bosentan, Carbamazepine. The full list is on the Drospirenone page.
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