Drug interactions
Drospirenone + Timolol
Severity: Minor
Drospirenone and Timolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has anti-mineralocorticoid activity and can raise serum potassium. Systemic beta-blockade, including absorbed ophthalmic or oral timolol, can modestly impair cellular potassium uptake. The combined effect is usually small but may matter in patients with renal impairment or other hyperkalemia risks.
What this interaction means in plain words
Drospirenone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Drospirenone belongs to Endocrine; Timolol belongs to Cardiovascular.
Why it happens
Additive tendency to raise potassium through drospirenone's anti-mineralocorticoid effect and beta-blocker impairment of cellular potassium uptake.
What to do
Check serum potassium in patients with renal impairment or other potassium-raising drugs when starting the combination. No routine action is required in healthy patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Drospirenone and Timolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Timolol?
MediHelp rates the interaction as minor. Drospirenone and Timolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone has anti-mineralocorticoid activity and can raise serum potassium. Systemic beta-blockade, including absorbed ophthalmic or oral timolol, can modestly impair cellular potassium uptake. The combined effect is usually small but may matter in patients with renal impairment or other hyperkalemia risks.
How serious is the interaction between Drospirenone and Timolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium in patients with renal impairment or other potassium-raising drugs when starting the combination. No routine action is required in healthy patients.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
