Drug interactions
Drospirenone + Tolmetin
Severity: Moderate
Drospirenone and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can increase potassium, and NSAIDs may add to this. Hyperkalemia is more likely in renal impairment or with other potassium-raising drugs.
What this interaction means in plain words
Drospirenone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Tolmetin belongs to Musculoskeletal.
Why it happens
Aldosterone antagonism by drospirenone combined with NSAID-induced reduction in renin, aldosterone and renal perfusion.
What to do
In patients on long-term NSAIDs, check serum potassium during the first cycle. Avoid in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Tolmetin?
MediHelp rates the interaction as moderate. Drospirenone and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can increase potassium, and NSAIDs may add to this. Hyperkalemia is more likely in renal impairment or with other potassium-raising drugs.
How serious is the interaction between Drospirenone and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In patients on long-term NSAIDs, check serum potassium during the first cycle. Avoid in renal impairment.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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