Drug interactions
Drospirenone + Trandolapril
Severity: Moderate
Drospirenone and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium. Combined with an ACE inhibitor, which reduces aldosterone, the risk of hyperkalemia increases, particularly with renal impairment or other potassium-raising agents.
What this interaction means in plain words
Drospirenone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Drospirenone belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive potassium retention through aldosterone antagonism (drospirenone) and reduced aldosterone production (ACE inhibition).
What to do
Check serum potassium during the first cycle of treatment and periodically thereafter. Avoid in patients with renal impairment or on other potassium-sparing therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Drospirenone with Trandolapril?
MediHelp rates the interaction as moderate. Drospirenone and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium. Combined with an ACE inhibitor, which reduces aldosterone, the risk of hyperkalemia increases, particularly with renal impairment or other potassium-raising agents.
How serious is the interaction between Drospirenone and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle of treatment and periodically thereafter. Avoid in patients with renal impairment or on other potassium-sparing therapy.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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