Drug interactions
Droxidopa + Epinephrine
Severity: Moderate
Droxidopa and Epinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droxidopa is converted to norepinephrine and raises blood pressure, and epinephrine adds further pressor and chronotropic effects. This can worsen supine hypertension and provoke tachyarrhythmias.
What this interaction means in plain words
Droxidopa and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Droxidopa belongs to Cardiovascular; Epinephrine belongs to Endocrine.
Why it happens
Additive pressor effect from norepinephrine formed from droxidopa and adrenergic receptor agonism by epinephrine.
What to do
Monitor blood pressure, including supine readings, and heart rate when the two are combined. Reduce or hold droxidopa if supine hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Epinephrine
- Epinephrine + Isocarboxazid Contraindicated
- Epinephrine + Phenelzine Contraindicated
- Epinephrine + Tranylcypromine Contraindicated
- Acebutolol + Epinephrine Major
- Amitriptyline + Epinephrine Major
- Amoxapine + Epinephrine Major
Other interactions of Droxidopa
- Droxidopa + Lisdexamfetamine Major
- Droxidopa + Methamphetamine Major
- Droxidopa + Pseudoephedrine Major
- Adrenaline-articaine + Droxidopa Moderate
- Almotriptan + Droxidopa Moderate
- Caffeine + Droxidopa Moderate
Frequently asked questions
Can I take Droxidopa with Epinephrine?
MediHelp rates the interaction as moderate. Droxidopa and Epinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droxidopa is converted to norepinephrine and raises blood pressure, and epinephrine adds further pressor and chronotropic effects. This can worsen supine hypertension and provoke tachyarrhythmias.
How serious is the interaction between Droxidopa and Epinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and heart rate when the two are combined. Reduce or hold droxidopa if supine hypertension develops.
What other medicines interact with Epinephrine?
MediHelp also lists interactions of Epinephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Epinephrine page.
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