Drug interactions
Dulaglutide + Insulin aspart
Severity: Moderate
Dulaglutide and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide enhances glucose-dependent insulin secretion and suppresses glucagon, so adding it to insulin increases the risk of hypoglycemia. The glucose-lowering effects are additive.
What this interaction means in plain words
Dulaglutide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from exogenous insulin and GLP-1 receptor agonism.
What to do
When starting dulaglutide, consider reducing the mealtime or total insulin dose and monitor blood glucose closely. Educate the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin aspart?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide enhances glucose-dependent insulin secretion and suppresses glucagon, so adding it to insulin increases the risk of hypoglycemia. The glucose-lowering effects are additive.
How serious is the interaction between Dulaglutide and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When starting dulaglutide, consider reducing the mealtime or total insulin dose and monitor blood glucose closely. Educate the patient about hypoglycemia symptoms.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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