Drug interactions
Glipizide + Insulin glargine-lixisenatide
Severity: Major
Glipizide and Insulin glargine-lixisenatide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glipizide stimulates insulin secretion, so combining it with insulin and lixisenatide raises the risk of hypoglycemia, which can be severe. The risk is higher in older patients and those with renal or hepatic impairment or irregular meals.
What this interaction means in plain words
Glipizide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glipizide belongs to Endocrine; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Additive glucose lowering from sulfonylurea-driven insulin secretion plus exogenous insulin and GLP-1 receptor agonism.
What to do
Consider reducing the glipizide dose when starting this product and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Glipizide
- Disopyramide + Glipizide Major
- Fluconazole + Glipizide Major
- Glipizide + Insulin degludec-liraglutide Major
- Glipizide + Sulfamethoxazole Major
- Aceclofenac + Glipizide Moderate
- Acemetacin + Glipizide Moderate
Frequently asked questions
Can I take Glipizide with Insulin glargine-lixisenatide?
MediHelp rates the interaction as major. Glipizide and Insulin glargine-lixisenatide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glipizide stimulates insulin secretion, so combining it with insulin and lixisenatide raises the risk of hypoglycemia, which can be severe. The risk is higher in older patients and those with renal or hepatic impairment or irregular meals.
How serious is the interaction between Glipizide and Insulin glargine-lixisenatide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glipizide dose when starting this product and monitor blood glucose closely. Educate the patient on recognizing and treating hypoglycemia.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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