Drug interactions
Dulaglutide + Insulin isophane human / insulin regular human
Severity: Moderate
Dulaglutide and Insulin isophane human / insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a GLP-1 receptor agonist with insulin lowers glucose more than either alone and raises the risk of hypoglycemia. Insulin doses often need reduction when dulaglutide is added.
What this interaction means in plain words
Dulaglutide and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering effects of glucose-dependent insulin secretion and exogenous insulin.
What to do
Monitor blood glucose frequently when starting dulaglutide and consider lowering the insulin dose. Educate the patient on hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin isophane human / insulin regular human?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a GLP-1 receptor agonist with insulin lowers glucose more than either alone and raises the risk of hypoglycemia. Insulin doses often need reduction when dulaglutide is added.
How serious is the interaction between Dulaglutide and Insulin isophane human / insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting dulaglutide and consider lowering the insulin dose. Educate the patient on hypoglycemia recognition.
What other medicines interact with Dulaglutide?
MediHelp also lists interactions of Dulaglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Dulaglutide page.
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