Drug interactions
Dulaglutide + Insulin lispro
Severity: Moderate
Dulaglutide and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide enhances glucose-dependent insulin secretion and, added to insulin, increases the risk of hypoglycemia. Insulin requirements often fall once the GLP-1 agonist is started.
What this interaction means in plain words
Dulaglutide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive glucose-lowering pharmacodynamic effects of exogenous insulin and GLP-1 receptor agonism.
What to do
When starting dulaglutide, consider reducing the mealtime insulin dose and monitor blood glucose closely. Educate the patient on recognising and treating hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin lispro?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide enhances glucose-dependent insulin secretion and, added to insulin, increases the risk of hypoglycemia. Insulin requirements often fall once the GLP-1 agonist is started.
How serious is the interaction between Dulaglutide and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: When starting dulaglutide, consider reducing the mealtime insulin dose and monitor blood glucose closely. Educate the patient on recognising and treating hypoglycemia.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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