Drug interactions
Dulaglutide + Insulin neutral human-insulin isophane protamine human
Severity: Moderate
Dulaglutide and Insulin neutral human-insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide combined with insulin increases the risk of hypoglycemia. Dulaglutide also slows gastric emptying, which may change postprandial glucose patterns.
What this interaction means in plain words
Dulaglutide and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dulaglutide belongs to Endocrine; Insulin neutral human-insulin isophane protamine human belongs to Endocrine.
Why it happens
Additive glucose lowering through glucose-dependent insulin secretion and glucagon suppression plus exogenous insulin.
What to do
Consider reducing the insulin dose when starting dulaglutide and monitor glucose frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Dulaglutide
Frequently asked questions
Can I take Dulaglutide with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as moderate. Dulaglutide and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dulaglutide combined with insulin increases the risk of hypoglycemia. Dulaglutide also slows gastric emptying, which may change postprandial glucose patterns.
How serious is the interaction between Dulaglutide and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the insulin dose when starting dulaglutide and monitor glucose frequently.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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