Drug interactions
Dutasteride-tamsulosin + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Dutasteride-tamsulosin and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat inhibits CYP3A4 and CYP2D6, both involved in tamsulosin metabolism, so tamsulosin levels may rise. This can cause hypotension, dizziness and syncope. Dutasteride levels may also increase.
What this interaction means in plain words
Dutasteride-tamsulosin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cobicistat inhibits CYP3A4 and CYP2D6, decreasing tamsulosin clearance.
What to do
Avoid if possible, particularly in patients with orthostatic hypotension. Otherwise monitor blood pressure and consider an alternative alpha-blocker or 5-ARI-only therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Dutasteride-tamsulosin with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Dutasteride-tamsulosin and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits CYP3A4 and CYP2D6, both involved in tamsulosin metabolism, so tamsulosin levels may rise. This can cause hypotension, dizziness and syncope. Dutasteride levels may also increase.
How serious is the interaction between Dutasteride-tamsulosin and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, particularly in patients with orthostatic hypotension. Otherwise monitor blood pressure and consider an alternative alpha-blocker or 5-ARI-only therapy.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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