Drug interactions
Dutasteride-tamsulosin + Encorafenib
Severity: Moderate
Dutasteride-tamsulosin and Encorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encorafenib can both inhibit and induce CYP3A4, so tamsulosin and dutasteride exposure could rise or fall unpredictably. The clinical effect is uncertain.
What this interaction means in plain words
Dutasteride-tamsulosin and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dutasteride-tamsulosin belongs to Genitourinary; Encorafenib belongs to Oncology.
Why it happens
Mixed CYP3A4 inhibition and induction by encorafenib altering tamsulosin and dutasteride metabolism.
What to do
Monitor for hypotension and dizziness, and for loss of symptom control. Adjust therapy according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Encorafenib
Frequently asked questions
Can I take Dutasteride-tamsulosin with Encorafenib?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Encorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Encorafenib can both inhibit and induce CYP3A4, so tamsulosin and dutasteride exposure could rise or fall unpredictably. The clinical effect is uncertain.
How serious is the interaction between Dutasteride-tamsulosin and Encorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypotension and dizziness, and for loss of symptom control. Adjust therapy according to response.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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