Drug interactions
Dutasteride-tamsulosin + Erythromycin ethylsuccinate
Severity: Moderate
Dutasteride-tamsulosin and Erythromycin ethylsuccinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and may increase exposure to both tamsulosin and dutasteride. Increased tamsulosin effects include dizziness and orthostatic hypotension.
What this interaction means in plain words
Dutasteride-tamsulosin and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal and hepatic CYP3A4 reducing metabolism of tamsulosin and dutasteride.
What to do
Monitor for orthostatic hypotension during short courses and counsel patients on dizziness. Consider an alternative antibiotic if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Dutasteride-tamsulosin with Erythromycin ethylsuccinate?
MediHelp rates the interaction as moderate. Dutasteride-tamsulosin and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and may increase exposure to both tamsulosin and dutasteride. Increased tamsulosin effects include dizziness and orthostatic hypotension.
How serious is the interaction between Dutasteride-tamsulosin and Erythromycin ethylsuccinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension during short courses and counsel patients on dizziness. Consider an alternative antibiotic if symptoms occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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