Drug interactions
Dutasteride-tamsulosin + Grapefruit
Severity: Minor
Dutasteride-tamsulosin and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may modestly raise tamsulosin and dutasteride exposure. The effect varies between individuals and is usually small. Higher tamsulosin levels could cause dizziness or hypotension.
What this interaction means in plain words
Dutasteride-tamsulosin and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Furanocoumarins in grapefruit inhibit intestinal CYP3A4, reducing first-pass metabolism.
What to do
Advise avoiding large or habitual grapefruit intake. Monitor for orthostatic symptoms if consumption is regular.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Dutasteride-tamsulosin with Grapefruit?
MediHelp rates the interaction as minor. Dutasteride-tamsulosin and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and may modestly raise tamsulosin and dutasteride exposure. The effect varies between individuals and is usually small. Higher tamsulosin levels could cause dizziness or hypotension.
How serious is the interaction between Dutasteride-tamsulosin and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding large or habitual grapefruit intake. Monitor for orthostatic symptoms if consumption is regular.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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