Drug interactions
Dutasteride-tamsulosin + Nafcillin
Severity: Minor
Dutasteride-tamsulosin and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin induces CYP3A4 and may lower tamsulosin and dutasteride exposure. Reduced efficacy is possible during prolonged therapy but unlikely with short courses.
What this interaction means in plain words
Dutasteride-tamsulosin and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin induces CYP3A4, increasing the clearance of tamsulosin and dutasteride.
What to do
No adjustment is usually needed for short courses. Monitor urinary symptoms if nafcillin is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Dutasteride-tamsulosin with Nafcillin?
MediHelp rates the interaction as minor. Dutasteride-tamsulosin and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin induces CYP3A4 and may lower tamsulosin and dutasteride exposure. Reduced efficacy is possible during prolonged therapy but unlikely with short courses.
How serious is the interaction between Dutasteride-tamsulosin and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed for short courses. Monitor urinary symptoms if nafcillin is prolonged.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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