Drug interactions
Duvelisib + Escitalopram
Severity: Minor
Duvelisib and Escitalopram: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4, which contributes to escitalopram metabolism, so escitalopram exposure may rise. The effect is probably modest because CYP2C19 is the main pathway, but it could increase adverse effects including QT prolongation.
What this interaction means in plain words
Duvelisib and Escitalopram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Duvelisib belongs to Oncology; Escitalopram belongs to Central Nervous System.
Why it happens
Duvelisib inhibition of CYP3A4-mediated metabolism of escitalopram.
What to do
Monitor for escitalopram adverse effects and consider a dose reduction if they appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Escitalopram?
MediHelp rates the interaction as minor. Duvelisib and Escitalopram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Duvelisib inhibits CYP3A4, which contributes to escitalopram metabolism, so escitalopram exposure may rise. The effect is probably modest because CYP2C19 is the main pathway, but it could increase adverse effects including QT prolongation.
How serious is the interaction between Duvelisib and Escitalopram?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for escitalopram adverse effects and consider a dose reduction if they appear.
What other medicines interact with Escitalopram?
MediHelp also lists interactions of Escitalopram with, for example, Cisapride, Citalopram, Isocarboxazid. The full list is on the Escitalopram page.
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