Drug interactions
Duvelisib + Fluticasone furoate
Severity: Moderate
Duvelisib and Fluticasone furoate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may raise fluticasone furoate exposure. This could increase corticosteroid systemic effects such as adrenal suppression, particularly with prolonged use.
What this interaction means in plain words
Duvelisib and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism by duvelisib.
What to do
Monitor for corticosteroid systemic effects and consider reducing fluticasone dose or using an alternative corticosteroid if prolonged use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Duvelisib with Fluticasone furoate?
MediHelp rates the interaction as moderate. Duvelisib and Fluticasone furoate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4 and may raise fluticasone furoate exposure. This could increase corticosteroid systemic effects such as adrenal suppression, particularly with prolonged use.
How serious is the interaction between Duvelisib and Fluticasone furoate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid systemic effects and consider reducing fluticasone dose or using an alternative corticosteroid if prolonged use is needed.
What other medicines interact with Duvelisib?
MediHelp also lists interactions of Duvelisib with, for example, Ergotamine, Alfuzosin, Apalutamide. The full list is on the Duvelisib page.
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